Which Is the Ideal Treatment for Benign Diffuse and Multinodular Non-Toxic Goiters?
نویسنده
چکیده
Patients with large benign goiters often present local compressive symptoms that require surgical treatment, including dysphagia, neck tightness, and airway obstruction. In contrast, patients with such goiters who remain asymptomatic may be observed after exclusion of malignancy. The use of levothyroxine (LT4) to reduce the volume of the goiter is still a controversial treatment for large goiters, and the optimal surgical procedure for multinodular goiter is still debatable. Radioiodine is a safe and effective treatment option when used alone or in combination with recombinant human TSH. This review discusses current therapeutic options to treat diffuse and multinodular non-toxic benign goiters.
منابع مشابه
Thyroid carcinoma in multinodular goiter
Background: It is suggested that hyperthyroidism protects against thyroid malignancy. It was suggested that the incidence of malignancy is lower in toxic multinodular goiters than in non-toxic multinodular goiters. Recent studies show controversies. Material and methods: The aim of this study is to determine the incidence and type of thyroid carcinoma in toxic and nontoxic multinodular goiter i...
متن کاملبررسی ده ساله 420 مورد تیروئید کتومی در بیمارستان شهید دکتر رهنمون
This is a retrospective study of 420 patients undergone thyroidectomy in Rahnemoon hospital during last 10 years. The results are as follows: Thyroid malignancies and surgical procedures were three times more common in female than male. Mean age was 38.2 years for male and 35.1 for female. For both sex 4th decade of life was the most common age of disease. 22% of patients had Positive family hi...
متن کاملRadioiodine treatment for non-toxic goitre
There is no ideal treatment for benign multinodular goitre. Besides surgery, which is recommended for large goitres or when malignancy cannot be excluded, the non-surgical treatment options are levothyroxine therapy and radioiodine ((131)I) therapy. Conventional (131)I therapy [without recombinant human thyroid-stimulating hormone (rhTSH)] has been used for more than a decade in symptomatic non...
متن کاملEvaluation and treatment of sporadic nontoxic goiter--some answers and more questions.
Sporadic nontoxic goiter (SNG) is defined as a benign enlargement of the thyroid gland in a euthyroid subject living in an iodine-sufficient area. Such goiters can be diffuse, uninodular, or multinodular and can vary greatly in size at presentation, growth rate, and symptomatology. The causes of SNG are incompletely understood, but include autoimmune, genetic, and extrinsic factors. SNG is a co...
متن کاملHyperfunctioning thyroid nodules in toxic multinodular goiter share activating thyrotropin receptor mutations with solitary toxic adenoma.
Toxic multinodular goiter is a cause of nonautoimmune hyperthyroidism and is believed to differ in its nature and pathogenesis from toxic adenoma. Gain-of-function mutations of the TSH receptor gene have been identified as a cause of toxic adenoma. The pathogenesis at the molecular level of hyperfunctioning nodules in toxic multinodular goiter has yet not been reported. Six patients with a sing...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2016